Koneramines are tridentate ligands that possess two N donors and a tertiary amine nitrogen donor in addition to another tertiary amine on the backbone which cannot participate in coordination. Koneramine synthesis is so general that it works with any monosubstituted-ethylenediamine, any pyridine-carboxaldehydes, any primary or secondary alcohols or thiols and any metal ions in open air; Fe, Co, Ni, Cu, Zn, Cd, Ru, Pd are among the metal ions present in isolated koneramine complexes. Indented koneramine complexes can be made directly as hemiaminal ether complexes from a reaction of monosubstituted-ethylenediamine, pyridine-carboxaldehydes, any primary or secondary alcohols or thiols, and any metal ions; then this complex can be strengthened by using NaBH4. Substrate binding coupled electron transfer will be achieved by combining redox and substrate binding functionalities to koneramine complex for the activation of small molecules, especially sulfur dioxide. Rationally designed koneramine complexes will be synthesized and their substrate binding (proton and sulfur dioxide mainly), electrochemical, and catalytic activation properties will be studied in detail.